Osteochondrogenesis with Autologous Peripheral Blood Stem Cells for Osteochondral Lesions of the Talus: Report of Five Cases

K Y Saw; Csy Jee; A Ramlan; A Dawam; Y C Saw; S F Low

doi:10.5704/MOJ.2211.019

Osteochondrogenesis with Autologous Peripheral Blood Stem Cells for Osteochondral Lesions of the Talus: Report of Five Cases

Malays Orthop J. 2022 Nov;16(3):128-131. doi: 10.5704/MOJ.2211.019.

Authors

K Y Saw¹, Csy Jee², A Ramlan², A Dawam², Y C Saw², S F Low³

Affiliations

¹ Department of Orthopaedic Surgery, Kuala Lumpur Sports Medicine Centre, Kuala Lumpur, Malaysia.
² Stem Cells Research and Development, Kuala Lumpur Sports Medicine Centre, Kuala Lumpur, Malaysia.
³ Department of Radiology, Kuala Lumpur Sports Medicine Centre, Kuala Lumpur, Malaysia.

Abstract

Osteochondral lesions of the talus (OLTs) may progress to ankle arthritis needing ankle arthroplasty or arthrodesis. We report five cases of OLTs treated along the principles developed for chondrogenesis of the knee joint with autologous peripheral blood stem cells (PBSCs), resulting in repair and regeneration of the bone and cartilage components. Improvement in Ankle Osteoarthritis Scale (AOS) scores with minimum two years follow-up showed statistical significance (p < 0.05).

Keywords: ankle osteoarthritis; marrow stimulation; osteochondral lesions of the talus; osteochondrogenesis; peripheral blood stem cells.

Publication types

Case Reports