Detailed radiosynthesis of [18 F]mG4P027 as a positron emission tomography radiotracer for mGluR4

J Labelled Comp Radiopharm. 2023 Feb;66(2):34-40. doi: 10.1002/jlcr.4011. Epub 2023 Jan 19.

Abstract

We report here the detailed radiosynthesis of [18 F]mG4P027, a metabotropic glutamate receptor 4 (mGluR4) PET radiotracer, which showed superior properties to the currently reported mGluR4 radiotracers. The radiosynthesis in the automated system has been challenging, therefore we disclose here the major limiting factors for the synthesis via step-by-step examination. And we hope this thorough study will help its automation for human use in the future.

Keywords: Parkinson's disease; mGluR4; positron emission tomography; radiosynthesis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Automation
  • Fluorine Radioisotopes
  • Humans
  • Positron-Emission Tomography / methods
  • Radiopharmaceuticals*
  • Receptors, Metabotropic Glutamate*

Substances

  • metabotropic glutamate receptor 4
  • Radiopharmaceuticals
  • Receptors, Metabotropic Glutamate
  • Fluorine Radioisotopes