Recurrence of primitive germ cell tumour 20 years on

BMJ Case Rep. 2023 Jan 4;16(1):e248093. doi: 10.1136/bcr-2021-248093.

Abstract

We present a case of a woman in her 20s, with a prior history of paediatric sacrococcygeal germ cell tumour, presenting with a 6-month history of perianal pain. An MRI pelvis revealed a heterogeneous soft tissue mass causing destruction of the sacrococcygeal bone. A staging CT demonstrated metastatic deposits in the lungs and hypodense foci in the liver suspicious of metastatic disease. Her alpha-fetoprotein levels were raised and a CT-guided biopsy was in keeping with recurrent germ cell tumour. She was referred to a national centre for the treatment of germ cell tumours in adults and was rechallenged with cisplatin-based multiagent chemotherapy with a curative intent. This case raises the important question of how long we should follow-up these patients and whether they can ever be safely discharged from oncology surveillance.

Keywords: Cancer intervention; Oncology.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Child
  • Cisplatin / therapeutic use
  • Female
  • Humans
  • Neoplasm Recurrence, Local*
  • Neoplasms, Germ Cell and Embryonal* / diagnostic imaging
  • Neoplasms, Germ Cell and Embryonal* / drug therapy

Substances

  • Cisplatin