An antibacterial and self-healing hydrogel from aldehyde-carrageenan for wound healing applications

This study aimed to develop and characterize a novel antibacterial, self-healing hydrogel made from aldehyde-carrageenan. Thus, carrageenan (CA) was first oxidized using different amounts of sodium periodate (NaIO₄), and the highest concentration of aldehyde was obtained when the ratio of NaIO₄ to CA was 1.5:1. Using dopamine (PDA) and zinc ions (Zn²⁺), various hydrogels were synthesized from oxidized carrageenan (O-CA). The effects of dopamine and zinc ions on the properties of O-CA hydrogel were examined. According to Fourier Transform Infrared Spectroscopy (FTIR) studies, the hydrogel's components are linked by Schiff bases, hydrogen bonds, and ion complexes. The rheological tests confirmed that hydrogels were elastic gels, not viscous sol, and were able to recover rapidly. Adding zinc to the hydrogel reduced weight loss (38 %) and provided extra antibacterial properties, particularly against E. coli. In addition, collagen secretion and cell attachment to Zn-containing hydrogels were significantly increased, and fibroblast viability reached 118 %. Overall, a hybrid O-CA/PDA/Zn hydrogel has excellent potential for wound healing applications.