CD8 tissue-resident memory T cells bridge the gap between humoral and cell-mediated immunity

Ying Shiang Lim; Haina Shin

doi:10.1016/j.mucimm.2023.01.002

CD8 tissue-resident memory T cells bridge the gap between humoral and cell-mediated immunity

Mucosal Immunol. 2023 Feb;16(1):3-4. doi: 10.1016/j.mucimm.2023.01.002. Epub 2023 Jan 11.

Authors

Ying Shiang Lim¹, Haina Shin²

Affiliations

¹ Department of Medicine/Division of Infectious Disease, Washington University School of Medicine, St Louis, Missouri, USA.
² Department of Medicine/Division of Infectious Disease, Washington University School of Medicine, St Louis, Missouri, USA. Electronic address: [email protected].

PMID: 36640865
DOI: 10.1016/j.mucimm.2023.01.002

Abstract

Tissue-resident memory T (T_RM) cells exert antiviral effects in situ using a variety of cell-intrinsic mechanisms. In this issue of Mucosal Immunology, Rosato and colleagues demonstrate that mucosal CD8 T_RM cells can also facilitate the extravasation of antibodies with neutralizing capacities by modulating transcytotic receptors and vascular permeability, thus revealing a new mechanism by which T_RM cells modulate humoral responses and protect the host from incoming pathogens.

MeSH terms

CD8-Positive T-Lymphocytes*
Immunity, Cellular
Immunologic Memory*
Memory T Cells
Mucous Membrane