Comparison of surgical outcomes between early and advanced class of jugular paragangliomas following application of our modified surgical techniques

Peng Zhao; Yibo Zhang; Feng Lin; Dedi Kong; Yisi Feng; Chunfu Dai

doi:10.1038/s41598-023-27821-y

Comparison of surgical outcomes between early and advanced class of jugular paragangliomas following application of our modified surgical techniques

Sci Rep. 2023 Jan 17;13(1):885. doi: 10.1038/s41598-023-27821-y.

Authors

Peng Zhao^{1

2

3}, Yibo Zhang^{4

5}, Feng Lin⁶, Dedi Kong^{1

2}, Yisi Feng^{1

2}, Chunfu Dai^{7

8}

Affiliations

¹ Department of Otology and Skull Base Surgery, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, 200031, China.
² Key Laboratory of Hearing Medicine, Ministry of Health, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, 200031, China.
³ Department of Otolaryngology Head and Neck Surgery, Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, 518102, China.
⁴ Department of Otology and Skull Base Surgery, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, 200031, China. [email protected].
⁵ Key Laboratory of Hearing Medicine, Ministry of Health, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, 200031, China. [email protected].
⁶ Department of Otolaryngology Head and Neck Surgery, Affiliated Nanping First Hospital, Fujian Medical University, Nanping, 353000, China.
⁷ Department of Otology and Skull Base Surgery, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, 200031, China. [email protected].
⁸ Key Laboratory of Hearing Medicine, Ministry of Health, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, 200031, China. [email protected].

Abstract

To compare the safety and effectiveness of surgical treatment of jugular paragangliomas (JPs) following the application of our modified surgical techniques. Fifty-six patients with JPs were analyzed for tumor classification, surgical outcomes, and intratumor blood vessels. The gross total resection in C1-2 (100%) was significantly greater than that in C3 and D (66.7%). Good postoperative facial nerve (FN) function (House-Brackmann I-II) was achieved in 89.5% C1-2 cases, which was not significantly different from C3 and D (93.3%) (P = 0.694). Preoperative and postoperative lower cranial nerve (LCN) deficits correlated with the Fisch's classification of tumors (P < 0.05), and intraoperative blood loss was greater in advanced tumors (P = 0.050). Further study showed that the cross-sectional area of intratumor blood vessels was positively associated with intraoperative blood loss (P < 0.001). Surgical excision of JPs is a safe and effective strategy, and early surgical treatment is a good option for patients with C1-2 tumors without surgical contraindications.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Blood Loss, Surgical*
Humans
Paraganglioma* / surgery
Postoperative Complications
Retrospective Studies
Treatment Outcome