In 2006, 2014 and 2020, the positive rates of HBsAg in 560, 384 and 402 children aged 1 to 14 years were 4.5%, 2.6% and 2.5%, respectively, with no statistically significant differences (P>0.05). The positive rate of anti-HBs was highest in 2014 (57.8%) and lowest in 2006 (34.1%) (P<0.05). The positive rate of anti-HBc was highest in 2006 (15.7%), and decreased in 2014 (7.8%) and 2020 (5.7%) (P<0.001). The timely rate of the first dose of hepatitis B vaccine for children in Lhasa in 2006, 2014 and 2020 was 7.7% (43/560), 50.3% (193/384) and 94.8% (381/402), respectively. The overall vaccination rates were 15.4% (86/560), 35.2% (135/384) and 96.0% (386/402), respectively, showing a trend of gradual increases (χtrend values were 718.63 and 589.59, both P values<0.001).
2006、2014和2020年，560、384和402名1~14岁儿童的HBsAg阳性率分别为4.5%、2.6%和2.5%，差异无统计学意义（P>0.05）；2014年抗-HBs阳性率（57.8%）最高，2006年最低（34.1%）（P<0.05）；2006年抗-HBc阳性率最高（15.7%），2014（7.8%）和2020年阳性率（5.7%）均有下降（P<0.001）。2006、2014和2020年拉萨市儿童乙肝疫苗首针及时率分别为7.7%（43/560）、50.3%（193/384）和94.8%（381/402），全程接种率分别为15.4%（86/560）、35.2%（135/384）和96.0%（386/402），均有逐渐升高的趋势（趋势χ2值分别为718.63、589.59，均P<0.001）。.