The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response

Ekaterina A Belousova; Olga I Lavrik

doi:10.3390/genes14010112

The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response

Genes (Basel). 2022 Dec 30;14(1):112. doi: 10.3390/genes14010112.

Authors

Ekaterina A Belousova¹, Olga I Lavrik¹

Affiliation

¹ Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Science, Novosibirsk 630090, Russia.

Abstract

The functioning of the eukaryotic cell genome is mediated by sophisticated protein-nucleic-acid complexes, whose minimal structural unit is the nucleosome. After the damage to genomic DNA, repair proteins need to gain access directly to the lesion; therefore, the initiation of the DNA damage response inevitably leads to local chromatin reorganisation. This review focuses on the possible involvement of PARP1, as well as proteins acting nucleosome compaction, linker histone H1 and non-histone chromatin protein HMGB1. The polymer of ADP-ribose is considered the main regulator during the development of the DNA damage response and in the course of assembly of the correct repair complex.

Keywords: DNA damage response; HMGB1; PAR; PARP1; histone H1; nucleosome core particle.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Triphosphate
Chromatin*
DNA / metabolism
DNA Damage / genetics
Nucleosomes* / genetics

Substances

Nucleosomes
Chromatin
DNA
Adenosine Triphosphate

Grants and funding

This research was funded by a grant from the Russian Science Foundation (No. 19-14-00204 to E.A.B.) and by the Russian state-funded project for ICBFM SB RAS (No. 121031300041-4 to O.I.L.).