Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold

Siva S Panda; Adel S Girgis; Marian N Aziz; Mohamed S Bekheit

doi:10.3390/molecules28020618

Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold

Molecules. 2023 Jan 7;28(2):618. doi: 10.3390/molecules28020618.

Authors

Siva S Panda¹, Adel S Girgis², Marian N Aziz², Mohamed S Bekheit²

Affiliations

¹ Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA.
² Department of Pesticide Chemistry, National Research Centre, Dokki, Giza 12622, Egypt.

Abstract

Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways. The present article summarizes the recent development of both natural and synthetic spirooxindole-containing compounds prepared from isatin or its derivatives reported in the last five years. The spirooxindoles are categorized based on their mentioned biological properties.

Keywords: alkaloids; biological properties; natural product; spirooxindole; synthesis.

Publication types

Review

MeSH terms

Indoles / chemistry
Isatin* / chemistry
Isatin* / pharmacology
Spiro Compounds* / chemistry
Spiro Compounds* / pharmacology

Substances

Indoles
Spiro Compounds
Isatin

Grants and funding

We thank the Augusta University Provost’s office, the Translational Research Program of the Department of Medicine, the Medical College of Georgia at Augusta University. This work was supported financially by National Research Centre, Egypt, project ID: 12060101.