Abstract
The results of treatment of the first 50 patients with hairy cell leukemia given human lymphoblastoid alpha-interferon (Wellferon) are presented. All patients, irrespective of previous splenectomy or splenomegaly showed evidence of response. Side effects were minor. Surface marker studies provided no clear indication of the mechanism of action of alpha-interferon. It is concluded that Wellferon is highly effective in this disease.
MeSH terms
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Adult
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Aged
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Antigens, Differentiation / analysis
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Antigens, Neoplasm / analysis
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Antigens, Surface / analysis
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Drug Administration Schedule
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Female
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Hematopoiesis
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Humans
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Interferon Type I / administration & dosage
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Interferon Type I / adverse effects
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Interferon Type I / therapeutic use*
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Leukemia, Hairy Cell / physiopathology
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Leukemia, Hairy Cell / therapy*
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Male
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Middle Aged
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Time Factors
Substances
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Antigens, Differentiation
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Antigens, Neoplasm
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Antigens, Surface
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Interferon Type I