Imaging in a new pediatric brain tumor-a supratentorial neuroepithelial tumor with PLAGL1 fusion

Childs Nerv Syst. 2023 Jun;39(6):1653-1656. doi: 10.1007/s00381-023-05830-6. Epub 2023 Jan 26.

Abstract

Molecular diagnostics have dramatically influenced the classification of tumor groups in the 2021 WHO CNS tumor classification. Studies focusing on molecular diagnostics continue to identify new tumors. Soon after the summary of the new classification was published, "Supratentorial Neuroepithelial Tumor with PLAGL1 Fusion" was described as a distinct entity. Although this new entity is defined pathologically, its imaging features are undefined. This case report discusses the imaging findings and possible differential diagnosis of the new tumor.

Keywords: Brain neoplasms; Central nervous system neoplasms; Epilepsy; Neoplasms.

Publication types

  • Case Reports

MeSH terms

  • Brain Neoplasms* / diagnostic imaging
  • Brain Neoplasms* / pathology
  • Brain Neoplasms* / surgery
  • Cell Cycle Proteins
  • Central Nervous System Neoplasms*
  • Child
  • Humans
  • Neoplasms, Neuroepithelial* / diagnostic imaging
  • Neoplasms, Neuroepithelial* / genetics
  • Neoplasms, Neuroepithelial* / surgery
  • Supratentorial Neoplasms* / pathology
  • Transcription Factors
  • Tumor Suppressor Proteins

Substances

  • PLAGL1 protein, human
  • Transcription Factors
  • Cell Cycle Proteins
  • Tumor Suppressor Proteins