Abstract
The reaction of m- or p-bromophenylsuccinic acids with 2-aminomethylpyridines yielded respective N-methylpyridylimides 1-8. Only compounds 1 and 6 show anticonvulsant activity in the pentetrazole and electric seizures tests, but their therapeutic index is inferior to that of ethosuximide and valproic acid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticonvulsants / chemical synthesis*
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Anticonvulsants / toxicity
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Chemical Phenomena
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Chemistry
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Chromatography, Thin Layer
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Lethal Dose 50
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Male
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Mice
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Nervous System Diseases / chemically induced
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Postural Balance / drug effects
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Pyridines / chemical synthesis*
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Pyridines / pharmacology
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Pyridines / toxicity
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Spectrophotometry, Ultraviolet
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Succinimides / chemical synthesis*
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Succinimides / pharmacology
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Succinimides / toxicity
Substances
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Anticonvulsants
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Pyridines
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Succinimides