Semaphorins and their receptors in pancreatic cancer: Mechanisms and therapeutic opportunities

Dahai Liu; Jie Li; Fei Qi; Hua You

doi:10.3389/fonc.2022.1106762

Semaphorins and their receptors in pancreatic cancer: Mechanisms and therapeutic opportunities

Front Oncol. 2023 Jan 13:12:1106762. doi: 10.3389/fonc.2022.1106762. eCollection 2022.

Authors

Dahai Liu¹, Jie Li¹, Fei Qi², Hua You^{3

4}

Affiliations

¹ School of Medicine, Foshan University, Foshan, Guangdong, China.
² Department of Pulmonary and Critical Care Medicine, Peking University Shenzhen Hospital, Shenzhen, China.
³ Department of Pediatric Hematology and Oncology, Children's Hospital of Chongqing Medical University, Chongqing, China.
⁴ Laboratory for Excellence in Systems Biomedicine of Pediatric Oncology, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.

Abstract

Pancreatic cancer (PC) is a malignant tumor with high malignancy that is difficult to diagnose and treat. PC is a major medical problem because of its low early diagnosis rate, high surgical mortality rate, low cure rate, and expensive related testing cost. Therefore, the significance of finding new markers for PC is self-evident. Semaphorins (Semas) have been shown to affect angiogenesis and lymphangiogenesis and can also directly affect the behavior of tumor cells. The expression and related action targets of its family members on PC are summarized in this review.

Keywords: Sema3; Sema4D; mechanisms; pancreatic cancer; semaphorins.

Publication types

Review

Grants and funding

The work in the Liu Lab is supported by The National Natural Science Foundation of China (Grant No. 82270413, 81870307), The Natural Science Foundation of Guangdong Province of China (Grant No. 2022A1515011368), and The Key Projects of Department of Education of Guangdong Province of China (Grant No. 2022ZDZX2057, 2022ZXKC474). The work in the You Lab is supported by The National Natural Science Foundation of China (Grant No. 81911530169).