A loosely coordinated interaction site for arachidonic acid on ASICs

J Gen Physiol. 2023 Mar 6;155(3):e202213307. doi: 10.1085/jgp.202213307. Epub 2023 Feb 1.

Abstract

Molecular dynamics simulations reveal a putative interaction surface for PUFAs on TM1 of ASICs that is not tightly conserved between isoforms.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Acid Sensing Ion Channels*
  • Arachidonic Acid
  • Neurons*

Substances

  • Arachidonic Acid
  • Acid Sensing Ion Channels