An HLA-homozygous haplobank resource to promote safer cell therapies

Glyn Nigel Stacey

doi:10.1016/j.stem.2023.01.003

An HLA-homozygous haplobank resource to promote safer cell therapies

Cell Stem Cell. 2023 Feb 2;30(2):118-119. doi: 10.1016/j.stem.2023.01.003.

Author

Glyn Nigel Stacey¹

Affiliation

¹ International Stem Cell Banking Initiative, 2 High Street, Barley SG88HZ, UK; National Stem Cell Resource Centre, Institute of Zoology, Chinese Academy of Sciences, Beijing 100190, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China; SSCBio Ltd, 2 High Street, Barley, Hertfordshire SG88HZ, UK. Electronic address: [email protected].

PMID: 36736287
DOI: 10.1016/j.stem.2023.01.003

Abstract

The generation of donor-derived induced pluripotent stem cells (iPSCs) for allogeneic transplantation is a major challenge in regenerative medicine. Yoshida et al. now report on the establishment of an HLA-homozygous haplobank of iPSCs that covers approximately 40% of the Japanese population and describe quality and safety considerations for manufacturing.

MeSH terms

Cell- and Tissue-Based Therapy*
Humans
Induced Pluripotent Stem Cells*
Regenerative Medicine
Tissue Donors
Transplantation, Homologous