[Advances in molecular genetics of mucosal melanoma]

H Li; Y M Lai; Y Wu; Z W Li

doi:10.3760/cma.j.cn112151-20220506-00369

[Advances in molecular genetics of mucosal melanoma]

Zhonghua Bing Li Xue Za Zhi. 2023 Feb 8;52(2):205-208. doi: 10.3760/cma.j.cn112151-20220506-00369.

[Article in Chinese]

Authors

H Li¹, Y M Lai², Y Wu², Z W Li²

Affiliations

¹ Department of Pathology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China.
² Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Department of Pathology, Peking University Cancer Hospital and Beijing Institute for Cancer Research, Beijing 100142, China.

PMID: 36748149
DOI: 10.3760/cma.j.cn112151-20220506-00369

Abstract

黏膜黑色素瘤是黑色素瘤中一种罕见且具有侵袭性的亚型，预后较差。在我国，黏膜黑色素瘤比例高达22.6%，是黑色素瘤诊断的主要亚型之一。随着下一代测序技术的不断发展，我们对黏膜黑色素瘤基因变异谱的了解逐渐深入。本文总结了黏膜黑色素瘤的分子遗传学研究进展，对黏膜黑色素瘤的主要驱动基因突变、结构变异及基因融合特征进行论述，有助于对该疾病的发病机制有更加深入的了解。.

MeSH terms

Humans
Melanoma* / genetics
Molecular Biology
Mucous Membrane