Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age

Affiliations

• ¹ Department of Cardiology, Medical University of Graz, Graz, Austria.
• ² Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le. cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.
• ³ Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.
• ⁴ BioTechMed Graz, Graz, Austria.
• ⁵ Institute of Molecular Biosciences, University of Graz, Graz, Austria.
• ⁶ Field of Excellence BioHealth, University of Graz, Graz, Austria.
• ⁷ Institute of Physiology, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
• ⁸ Department of Biology, Institut du Cancer Paris CARPEM, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.