Discovery of pentacyclic triterpenoid glycosides with anti-proliferative activities from Ardisialindleyana

Zhen-Zhen Wei; Ti-Qiang Zhou; Jing-Rui Zhang; Zi-Ming Xia; Si-Fan Liu; Chun-Ying Liu; Min Li; Guang-Jie Zhang; Ying Tian; Bin Li; Lin Wang; Shu-Chen Liu

doi:10.1016/j.carres.2023.108761

Discovery of pentacyclic triterpenoid glycosides with anti-proliferative activities from Ardisialindleyana

Carbohydr Res. 2023 Feb:524:108761. doi: 10.1016/j.carres.2023.108761. Epub 2023 Feb 4.

Authors

Zhen-Zhen Wei¹, Ti-Qiang Zhou², Jing-Rui Zhang³, Zi-Ming Xia⁴, Si-Fan Liu⁴, Chun-Ying Liu³, Min Li⁴, Guang-Jie Zhang⁴, Ying Tian⁵, Bin Li⁶, Lin Wang⁷, Shu-Chen Liu⁸

Affiliations

¹ Faculty of Environment and Life, Beijing University of Technology, Beijing, 100022, China; Department of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing, 100850, China.
² School of Life Science, Advanced Research Institute of Multidisciplinary Science, Institute of Engineering Medicine, Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing, 100081, China.
³ Department of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing, 100850, China; School of Pharmacy, Henan University, Kaifeng, 475001, China.
⁴ Department of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing, 100850, China.
⁵ Department of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing, 100850, China. Electronic address: [email protected].
⁶ Department of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing, 100850, China. Electronic address: [email protected].
⁷ Faculty of Environment and Life, Beijing University of Technology, Beijing, 100022, China; Department of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing, 100850, China. Electronic address: [email protected].
⁸ Department of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing, 100850, China. Electronic address: [email protected].

PMID: 36753889
DOI: 10.1016/j.carres.2023.108761

Abstract

One new pentacyclic triterpenoid glycoside, ardisiapunine E (1), along with two known compounds were isolated from the root of Ardisia lindleyana D.Dietr. Their structures were elucidated by ¹H and ¹³C NMR, DEPT, HMBC, HSQC, ¹H-¹H COSY and NOESY spectroscopic analyses, ESI-MS, and literature. Compounds 1-3 exhibited obvious anti-proliferative activities against the HeLa cell line in a dose- and time-dependent manner by inducing G2/M phase arrest and apoptosis in vitro, both consisting of pentacyclic triterpenes and sugar. Hence, this study identified a new and two known pentacyclic triterpenoid glycosides promoting apoptosis as a potential anti-proliferative agent.

Keywords: Anti-proliferative activity; Apoptosis; Ardisia lindleyana; Glycoside; Triterpenoid.

MeSH terms

Glycosides* / chemistry
HeLa Cells
Humans
Molecular Structure
Pentacyclic Triterpenes
Triterpenes* / chemistry

Substances

Glycosides
Triterpenes
Pentacyclic Triterpenes