Abstract
The kinetic interaction between salicylate and naproxen was investigated in 25 rheumatoid arthritis patients. Kinetic interactions were tested in serum after patients had been on each drug regimen for 1 month. Salicylate decreased serum naproxen concentration from 89.5 mg/liter to 65.9 mg/liter (P less than 0.001) and increased serum naproxen clearance by 56%. Naproxen had minimal effect on serum salicylate concentrations.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Arthritis, Rheumatoid / blood
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Arthritis, Rheumatoid / drug therapy*
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Choline / analogs & derivatives*
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Choline / blood
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Choline / pharmacokinetics
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Choline / therapeutic use
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Double-Blind Method
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Drug Interactions
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Drug Therapy, Combination
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Humans
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Metabolic Clearance Rate / drug effects
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Naproxen / blood
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Naproxen / pharmacokinetics*
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Naproxen / therapeutic use
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Random Allocation
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Salicylates / blood
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Salicylates / pharmacokinetics*
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Salicylates / therapeutic use
Substances
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Salicylates
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Naproxen
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choline magnesium trisalicylate
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Choline