Versatile use of bat ACE2 for cellular entry by MERS-CoV-like viruses

Kaushal Baid; Arinjay Banerjee

doi:10.1016/j.chom.2022.12.013

Versatile use of bat ACE2 for cellular entry by MERS-CoV-like viruses

Cell Host Microbe. 2023 Feb 8;31(2):161-163. doi: 10.1016/j.chom.2022.12.013.

Authors

Kaushal Baid¹, Arinjay Banerjee²

Affiliations

¹ Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada.
² Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada; Department of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: [email protected].

Abstract

Cellular entry receptors for bat MERS-CoV-like viruses NeoCoV and PDF-2180 were unknown, leaving their zoonotic potential ambiguous. A recent study by Xiong et al. published in Nature identified bat ACE2 as the cellular entry receptor for both viruses, highlighting the ability of coronaviruses to utilize a range of entry receptors.

MeSH terms

Angiotensin-Converting Enzyme 2
Animals
Cell Line
Chiroptera*
Coronavirus Infections*
Humans
Middle East Respiratory Syndrome Coronavirus*
Spike Glycoprotein, Coronavirus

Substances

Angiotensin-Converting Enzyme 2
Spike Glycoprotein, Coronavirus

Grants and funding

R21 AI169527/AI/NIAID NIH HHS/United States