Rational design of HJH antimicrobial peptides to improve antimicrobial activity

Bioorg Med Chem Lett. 2023 Mar 1:83:129176. doi: 10.1016/j.bmcl.2023.129176. Epub 2023 Feb 8.

Abstract

Antimicrobial peptides (AMPs) have attracted considerable interest in the past decade due to their advantages for tackling antibiotic resistance. They exhibit potential antimicrobial activity through unique cell membrane destruction mechanism based on their net charge, hydrophobic properties, and α-helix. In this work, a series of HJH peptides was rationally designed and synthesized. The antimicrobial activity and cytotoxicity assays indicated that HJH-5 and HJH-6 containing hydrophobic residues and helices displayed prominent antimicrobial activity and mild cytotoxicity, respectively. These peptides may be developed for combatting microbial infections.

Keywords: Antimicrobial activity; Antimicrobial peptides; HJH-1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Anti-Infective Agents* / chemistry
  • Anti-Infective Agents* / pharmacology
  • Antimicrobial Cationic Peptides* / chemistry
  • Antimicrobial Cationic Peptides* / pharmacology
  • Antimicrobial Peptides
  • Cell Membrane
  • Drug Resistance, Microbial
  • Microbial Sensitivity Tests

Substances

  • Antimicrobial Cationic Peptides
  • Antimicrobial Peptides
  • Anti-Infective Agents
  • Anti-Bacterial Agents