Global, regional, and national incidence and prevalence of systemic sclerosis

Jingru Tian; Shuntong Kang; Dingyao Zhang; Yaqing Huang; Ming Zhao; Xianhua Gui; Xu Yao; Qianjin Lu

doi:10.1016/j.clim.2023.109267

Global, regional, and national incidence and prevalence of systemic sclerosis

Clin Immunol. 2023 Mar:248:109267. doi: 10.1016/j.clim.2023.109267. Epub 2023 Feb 15.

Authors

Jingru Tian¹, Shuntong Kang², Dingyao Zhang³, Yaqing Huang⁴, Ming Zhao⁵, Xianhua Gui⁶, Xu Yao⁷, Qianjin Lu⁸

Affiliations

¹ Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China.
² Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
³ Graduate Program in Biological and Biomedical Sciences, Yale University, New Haven, USA; Program in Computational Biology and Bioinformatics, Yale University, New Haven, USA.
⁴ Department of Pathology, Yale University, New Haven, USA.
⁵ Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China; Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁶ Department of Respiratory Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China. Electronic address: [email protected].
⁷ Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China. Electronic address: [email protected].
⁸ Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China. Electronic address: [email protected].

PMID: 36804224
DOI: 10.1016/j.clim.2023.109267

Abstract

Objectives: To estimate the global and country-specific unbiased epidemiological data of SSc.

Methods: Epidemiological studies were systematically searched in four databases. A Bayesian hierarchical linear mixed model was constructed to estimate epidemiological data.

Results: 82 studies were included and epidemiological data on SSc were missing for 83.9% of countries worldwide. The global SSc incidence and newly diagnosed population were estimated to be 8.64 per 100,000 person-years (1.78-23.57) and 0.67 million (0.14-1.84) people annually, respectively. Regarding prevalence, the global SSc prevalence and affected population were 18.87 per 100,000 persons (1.55-25.28) and 1.47 million (0.12-1.97) people, respectively. Relatively higher incidence and prevalence were observed in females, adults, and high-income level countries.

Conclusions: We provide a comprehensive synthesis of SSc epidemiology and fill data gaps in most countries. Especially in low- and middle-income countries, epidemiological studies of SSc are insufficient. Further large-scale and standardized reported epidemiological investigations of SSc are imperative.

Keywords: Epidemiology; Incidence; Prevalence; Systemic sclerosis; Worldwide.

Publication types

Systematic Review
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Bayes Theorem
Databases, Factual
Female
Humans
Incidence
Prevalence
Scleroderma, Systemic* / diagnosis