Current landscape and future directions of synthetic biology in South America

Front Bioeng Biotechnol. 2023 Feb 10:11:1069628. doi: 10.3389/fbioe.2023.1069628. eCollection 2023.

Abstract

Synthetic biology (SynBio) is a rapidly advancing multidisciplinary field in which South American countries such as Chile, Argentina, and Brazil have made notable contributions and have established leadership positions in the region. In recent years, efforts have strengthened SynBio in the rest of the countries, and although progress is significant, growth has not matched that of the aforementioned countries. Initiatives such as iGEM and TECNOx have introduced students and researchers from various countries to the foundations of SynBio. Several factors have hindered progress in the field, including scarce funding from both public and private sources for synthetic biology projects, an underdeveloped biotech industry, and a lack of policies to promote bio-innovation. However, open science initiatives such as the DIY movement and OSHW have helped to alleviate some of these challenges. Similarly, the abundance of natural resources and biodiversity make South America an attractive location to invest in and develop SynBio projects.

Keywords: DIY; Latin America; Open science; South America; SynBio; TECNOx.

Publication types

  • Review

Grants and funding

This work was supported by São Paulo State Foundation (FAPESP, award 2021/01748-5). The financial support of The Novo Nordisk Foundation through grants NNF20CC0035580, LiFe (NNF18OC0034818), and TARGET (NNF21OC0067996), the Danish Council for Independent Research (SWEET, DFF-Research Project 8021-00039B), the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No. 814418 (SinFonia), and the Cystic Fibrosis Trust, Strategic Research Centre Award–2019–SRC017 to PN is gratefully acknowledged. Uruguayan Basic Science Development Program (PEDECIBA) and National Agency for Investigation and Innovation (ANII) award FCE_1_2019_1_156520. This work was also supported by the Universidad San Francisco de Quito through Escuela de Medicina, Colegio de Ciencias de la Salud (COCSA).