Production of Co-58m in a siphon-style liquid target on a medical cyclotron

L Mues Genannt Koers; S W McNeil; V Radchenko; E Paulssen; C Hoehr

doi:10.1016/j.apradiso.2023.110734

Production of Co-58m in a siphon-style liquid target on a medical cyclotron

Appl Radiat Isot. 2023 May:195:110734. doi: 10.1016/j.apradiso.2023.110734. Epub 2023 Feb 26.

Authors

L Mues Genannt Koers¹, S W McNeil², V Radchenko¹, E Paulssen³, C Hoehr⁴

Affiliations

¹ Life Sciences Division, TRIUMF, 4004 Wesbrook Mall, Vancouver, BC, V6T2A3, Canada; Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, V6T 1Z1, Canada.
² Life Sciences Division, TRIUMF, 4004 Wesbrook Mall, Vancouver, BC, V6T2A3, Canada.
³ Department of Chemistry and Biotechnology, FH Aachen - University of Applied Sciences, Heinrich-Mußmann-Straße 1, Germany; Delft University of Technology, Department Radiation Science and Technology, Mekelweg 15, 2629JB Delft, the Netherlands.
⁴ Life Sciences Division, TRIUMF, 4004 Wesbrook Mall, Vancouver, BC, V6T2A3, Canada; Department of Physics and Astronomy, University of Victoria, 3800 Finnerty Road, Victoria, British Columbia, V8P 5C2, Canada; Department of Computer Science, Mathematics, Physics and Statistics, University of British Columbia Okanagan, 3187 University Way, Kelowna, British Columbia, V1V 1V7, Canada. Electronic address: [email protected].

PMID: 36863263
DOI: 10.1016/j.apradiso.2023.110734

Abstract

We present the production of ^58mCo on a small, 13 MeV medical cyclotron utilizing a siphon style liquid target system. Different concentrated iron(III)-nitrate solutions of natural isotopic distribution were irradiated at varying initial pressures and subsequently separated by solid phase extraction chromatography. The radio cobalt (^⁵⁸m/gCo and ⁵⁶Co) was successfully produced with saturation activities of (0.35 ± 0.03) MBq μA^-1 for ^58mCo with a separation recovery of (75 ± 2) % of cobalt after one separation step utilizing LN-resin.

Keywords: Cobalt-58m; Cyclotron production; Liquid target; Meitner-Auger therapy; Radiometal; Small medical cyclotron.