13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue

Alexander M Barclay; Dhruva D Dhavale; Collin G Borcik; Moses H Milchberg; Paul T Kotzbauer; Chad M Rienstra

doi:10.21203/rs.3.rs-2460685/v1

13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue

Res Sq [Preprint]. 2023 Feb 24:rs.3.rs-2460685. doi: 10.21203/rs.3.rs-2460685/v1.

Authors

Alexander M Barclay¹, Dhruva D Dhavale², Collin G Borcik³, Moses H Milchberg³, Paul T Kotzbauer², Chad M Rienstra³

Affiliations

¹ University of Illinois at Urbana-Champaign.
² Washington University School of Medicine.
³ University of Wisconsin-Madison.

Abstract

Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of ¹³C, ¹⁵N assignments that are unique to fibrils obtained by amplification from postmortem brain tissue of a patient diagnosed with Lewy Body Dementia.

Keywords: Fibrils; Lewy Body Dementia; Parkinson Disease; Polymorphism; α-Synuclein.

Publication types

Preprint

Abstract

Publication types

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