Corticosteroids Decrease the Incidence and Activity of Choroidal Neovascularization in Patients with Punctuate Inner Choroidopathy or Multifocal Choroiditis

Ocul Immunol Inflamm. 2024 Jul;32(5):602-608. doi: 10.1080/09273948.2023.2181189. Epub 2023 Mar 3.

Abstract

Purpose: To assess the effect of corticosteroids (CS) on choroidal neovascularization (CNV) occurrence and recurrence of activity over 2 years in patients with punctate inner choroidopathy (PIC) or multifocal choroiditis (MFC).

Methods: Retrospective longitudinal study. Previous use of CS was analyzed between group without CNV and group with CNV occurrence and recurrence.

Results: Thirty-six patients were included. Patients with CNV were less likely to have received CS in the 6 months following PIC or MFC diagnosis (17% versus 65%, p-value = 0.01). Patients with CNV who had a recurrence of neovascular activity were less likely to have received a previous CS therapy (20% versus 78%; odds ratio = 0.08, p-value = 0.005).

Conclusions: This study suggests that patients with PIC and MFC should be treated by CS to prevent CNV development and decrease CNV recurrences.

Keywords: Choroidal neovascularization; corticosteroids; multifocal choroiditis; posterior uveitis; punctate inner choroidopathy.

MeSH terms

  • Adult
  • Choroid / blood supply
  • Choroidal Neovascularization* / diagnosis
  • Choroidal Neovascularization* / drug therapy
  • Choroiditis / diagnosis
  • Choroiditis / drug therapy
  • Female
  • Fluorescein Angiography*
  • Follow-Up Studies
  • Fundus Oculi
  • Glucocorticoids* / therapeutic use
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Multifocal Choroiditis*
  • Recurrence
  • Retrospective Studies
  • Tomography, Optical Coherence*
  • Visual Acuity*
  • White Dot Syndromes / diagnosis
  • White Dot Syndromes / drug therapy
  • Young Adult

Substances

  • Glucocorticoids