Proteomics and metabolomics analysis of nasal lavage fluid in chronic rhinosinusitis with nasal polyps

Yujuan Yang; Jing Guo; Yao Yao; Jianwei Wang; Jiali Yin; Ying Guo; Cai Wang; Yu Zhang; Xicheng Song

doi:10.1002/alr.23151

Proteomics and metabolomics analysis of nasal lavage fluid in chronic rhinosinusitis with nasal polyps

Int Forum Allergy Rhinol. 2023 Oct;13(10):1966-1970. doi: 10.1002/alr.23151. Epub 2023 Mar 23.

Authors

Yujuan Yang^{1

2}, Jing Guo^{1

2}, Yao Yao^{1

2}, Jianwei Wang^{1

2}, Jiali Yin^{1

2}, Ying Guo^{1

2}, Cai Wang^{1

2}, Yu Zhang^{1

2}, Xicheng Song^{1

2}

Affiliations

¹ Department of Otolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
² Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China.

PMID: 36898695
DOI: 10.1002/alr.23151

Abstract

An integrated proteomics and metabolomics were used to investigate the pathogenesis of CRSwNP. Amino acid metabolism and mitochondrial dysfunction play key roles in the pathogenesis of CRSwNP.

Keywords: CRSwNP; amino acid metabolism; metabolomics; mitochondrial dysfunction; proteomics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chronic Disease
Humans
Nasal Lavage Fluid
Nasal Polyps* / pathology
Proteomics
Rhinitis* / pathology
Sinusitis* / pathology