γδ T cells turn the tables on immune-evasive colon cancer

Med. 2023 Mar 10;4(3):141-142. doi: 10.1016/j.medj.2023.02.007.

Abstract

Why is checkpoint blockade immunotherapy still effective in tumors that are unrecognizable to CD8+ T cells? In a recent study published in Nature, de Vries et al.1 provide evidence that the lesser-known γδ T cell population may mediate beneficial responses to immune checkpoint blockade when cancer cells lose HLA expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • CD8-Positive T-Lymphocytes* / metabolism
  • Colonic Neoplasms* / metabolism
  • Humans