Mechanisms of the "No-Reflow" Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes

Sanjiv Kaul; Carmen Methner; Zhiping Cao; Anusha Mishra

doi:10.1016/j.jacbts.2022.06.008

Mechanisms of the "No-Reflow" Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes

JACC Basic Transl Sci. 2022 Sep 21;8(2):204-220. doi: 10.1016/j.jacbts.2022.06.008. eCollection 2023 Feb.

Authors

Sanjiv Kaul¹, Carmen Methner¹, Zhiping Cao¹, Anusha Mishra^{1

2}

Affiliations

¹ Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA.
² Jungers Center for Neurosciences Research, Department of Neurology, School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.

Abstract

Pericytes contract during myocardial ischemia resulting in capillary constriction and no reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size. These findings open up an entire new venue of research aimed at altering pericyte function in myocardial ischemia and infarction.

Keywords: CHP, capillary hydrostatic pressure; MBF, myocardial blood flow; MCE, myocardial contrast echocardiography; NG2, neural glial antigen-2; acute myocardial infarction; blood flow; necrosis; no reflow; pericytes.

Publication types

Review