ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis

Chun-Miao Deng; Guo-Geng Zhang; Qin-Wen Liu; Jiao-Jiao Xu; Zhi-Chao Liu; Jing Yang; Tao-Yang Xu; Zhi-Gang Li; Fan Zhang; Bin Li

doi:10.1158/0008-5472.CAN-22-3490

ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis

Cancer Res. 2023 Jun 2;83(11):1851-1865. doi: 10.1158/0008-5472.CAN-22-3490.

Authors

Chun-Miao Deng^#¹, Guo-Geng Zhang^#¹, Qin-Wen Liu^#¹, Jiao-Jiao Xu¹, Zhi-Chao Liu², Jing Yang¹, Tao-Yang Xu¹, Zhi-Gang Li², Fan Zhang³, Bin Li¹

Affiliations

¹ Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, State Key Laboratory of Respiratory Disease, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
² Department of Thoracic Surgery, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
³ Department of Gastrointestinal Surgery, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

^# Contributed equally.

PMID: 36912612
DOI: 10.1158/0008-5472.CAN-22-3490

Abstract

Metastatic cancer cells upregulate ANO1 to activate cell-intrinsic and -extrinsic mechanisms that alter cholesterol metabolism and stimulate fibroblasts, which can be targeted with ANO1 inhibitors to inhibit metastatic growth. See related commentary by Singh and Mehla, p. 1759.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anoctamin-1 / metabolism
Cell Line, Tumor
Cholesterol / metabolism
Fibroblasts / metabolism
Humans
Neoplasm Proteins* / metabolism
Neoplasms* / metabolism
Tumor Microenvironment

Substances

Neoplasm Proteins
Cholesterol
Anoctamin-1
ANO1 protein, human