Pyrroloiminoquinone Alkaloids: Total Synthesis of Makaluvamines A and K

Org Lett. 2023 Mar 24;25(11):1868-1871. doi: 10.1021/acs.orglett.3c00350. Epub 2023 Mar 13.

Abstract

Herein, an efficient, scalable, and concise approach to an advanced pyrroloiminoquinone synthetic intermediate (6b) by way of a Larock indole synthesis is reported. The synthetic utility of this intermediate is demonstrated by its ready conversion to makaluvamines A (1) and K (4).