Comparative results of 327 chemical carcinogenicity studies

Environ Health Perspect. 1987 Oct:74:229-35. doi: 10.1289/ehp.8774229.

Abstract

The National Cancer Institute (NCI) and the National Toxicology Program (NTP) have carried out a number of laboratory animal carcinogenicity studies and presented the results of these experiments in a series of Technical Reports. This paper tabulates the results of the 327 NCI/NTP studies carried out to date on 308 distinct chemicals, and discusses certain issues relevant to the evaluation of carcinogenicity in these experiments. This compilation of results from NCI/NTP carcinogenicity experiments provides a large database that can be used to study structure-activity correlations, interspecies concordance, and associations between laboratory animal carcinogenicity and other toxicological effects.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Carcinogens / toxicity*
  • Female
  • Male
  • Mice
  • Mutagenicity Tests*
  • National Institutes of Health (U.S.)
  • Neoplasms, Experimental / chemically induced*
  • Rats
  • United States

Substances

  • Carcinogens