Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions

Chun-Chieh Chen; Shih-Sheng Chang; Chih-Hsiang Chang; Chih-Chien Hu; Yoshihiro Nakao; Shan May Yong; Yen Ling Ow Mandy; Chia Juan Lim; Eric Kian-Shiun Shim; Hsin-Nung Shih

doi:10.1186/s12937-023-00837-w

Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions

Nutr J. 2023 Mar 15;22(1):17. doi: 10.1186/s12937-023-00837-w.

Authors

Chun-Chieh Chen^{1

2

3}, Shih-Sheng Chang^{1

2

3}, Chih-Hsiang Chang^{1

2

3

4}, Chih-Chien Hu^{1

2

3}, Yoshihiro Nakao⁵, Shan May Yong⁵, Yen Ling Ow Mandy⁵, Chia Juan Lim⁵, Eric Kian-Shiun Shim⁵, Hsin-Nung Shih^{6

7

8}

Affiliations

¹ Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing Street, Guishan District, Taoyuan City 333, Taiwan.
² College of Medicine, Chang Gung University, No. 259, Wenhua 1st Road, Guishan District, Taoyuan City, 333, Taiwan.
³ Bone and Joint Research Center, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing Street, Guishan District, Taoyuan City, 333, Taiwan.
⁴ Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, No. 259, Wenhua 1St Road, Guishan District, Taoyuan City, 333, Taiwan.
⁵ Research and Development, Suntory Beverage and Food Asia, 3 Biopolis Drive, #06-14/19, Synapse, Singapore, 138623, Singapore.
⁶ Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing Street, Guishan District, Taoyuan City 333, Taiwan. [email protected].
⁷ College of Medicine, Chang Gung University, No. 259, Wenhua 1st Road, Guishan District, Taoyuan City, 333, Taiwan. [email protected].
⁸ Bone and Joint Research Center, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing Street, Guishan District, Taoyuan City, 333, Taiwan. [email protected].

Abstract

Background: Knee osteoarthritis (OA) is a leading cause of disability among older adults. Medical and surgical treatments are costly and associated with side effects. A natural nutraceutical, collagen hydrolysate, has received considerable attention due to its relieving effects on OA-associated symptoms. This study investigated the effects of hydrolyzed collagen type II (HC-II) and essence of chicken (BRAND'S Essence of Chicken) with added HC-II (EC-HC-II) on joint, muscle, and bone functions among older adults with OA.

Methods: Patients (n = 160) with grade 1-3 knee OA according to the Kellgren-Lawrence classification system, joint pain for ≥ 3 months, and a Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score of > 6 were randomly assigned with equal probability to consume EC-HC-II, HC-II, glucosamine HCl, or a placebo for 24 weeks in combination with resistance training. Outcome measurements were WOMAC score, visual analogue scale (VAS) pain score, grip strength, fat-free mass (FFM), and bone mass.

Results: All groups exhibited similar levels of improvement in WOMAC index scores after 24 weeks. HC-II significantly reduced VAS pain score by 0.9 ± 1.89 (p = 0.034) after 14 days. A repeated-measures analysis of variance showed that HC-II reduced pain levels more than the placebo did (mean ± standard error: - 1.3 ± 0.45, p = 0.021) after 14 days; the EC-HC-II group also had significantly higher FFM than the glucosamine HCl (p = 0.02) and placebo (p = 0.017) groups and significantly higher grip strength than the glucosamine HCl group (p = 0.002) at 24 weeks.

Conclusion: HC-II reduces pain, and EC-HC-II may improve FFM and muscle strength. This suggests that EC-HC-II may be a novel holistic solution for mobility by improving joint, muscle, and bone health among older adults. Large-scale studies should be conducted to validate these findings.

Trial registration: This trial was retrospectively registered at ClinicalTrials.gov (NCT04483024).

Keywords: Chicken essence; Collagen hydrolysate; Joint pain; Knee osteoarthritis; Nutritional supplements.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chickens*
Collagen Type II / therapeutic use
Double-Blind Method
Glucosamine / therapeutic use
Humans
Muscles
Osteoarthritis, Knee* / complications
Osteoarthritis, Knee* / drug therapy
Pain / complications
Pain / drug therapy
Pilot Projects
Treatment Outcome

Substances

Collagen Type II
Glucosamine

Associated data

ClinicalTrials.gov/NCT04483024