The Ability of Near-Infrared Spectroscopy to Identify Vulnerable Patients and Plaques: A Systematic Review and Meta-Analysis

Ronald D Bass; Joseph Phillips; Jorge Sanz Sánchez; Priti Shah; Stephen Sum; Ron Waksman; Hector M Garcia-Garcia

doi:10.1016/j.iccl.2022.10.006

The Ability of Near-Infrared Spectroscopy to Identify Vulnerable Patients and Plaques: A Systematic Review and Meta-Analysis

Interv Cardiol Clin. 2023 Apr;12(2):245-256. doi: 10.1016/j.iccl.2022.10.006. Epub 2023 Jan 31.

Authors

Ronald D Bass¹, Joseph Phillips², Jorge Sanz Sánchez³, Priti Shah⁴, Stephen Sum⁴, Ron Waksman⁵, Hector M Garcia-Garcia⁶

Affiliations

¹ School of Medicine, Georgetown University, 3800 Reservoir Road, NorthWest, Washington, DC 20007, USA.
² University of Iowa Hospitals and Clinics, 200 Hawkins Drive Iowa City, IA 52242, USA.
³ Hospital Universitari I Politecnic La Fe, Avinguda de Fernando Abril Martorell, no 106, 46026 València, Spain; Centro de Investigación Biomedica en Red (CIBERCV), Avenue, Monforte de Lemos, 3-5. Pabellón 11. Planta 0. 28029 Madrid, Spain.
⁴ InfraRedx, A Nipro Company, 28 Crosby Drive, Suite 100, Bedford, MA 01730, USA.
⁵ Interventional Cardiology, MedStar Washington Hospital Center, 110 Irving Street, Suite 4B-1, Washington, DC, 20010, USA.
⁶ Interventional Cardiology, MedStar Washington Hospital Center, 110 Irving Street, Suite 4B-1, Washington, DC, 20010, USA. Electronic address: [email protected].

PMID: 36922065
DOI: 10.1016/j.iccl.2022.10.006

Abstract

Previous studies have analyzed the efficacy of near-infrared spectroscopy-derived lipid core burden index (LCBI) in quantifying and identifying high-risk plaques and patients at increased risk of future major adverse cardiac outcomes/major adverse cardiovascular and cerebrovascular events. A maxLCBI_4mm of 400 or greater seems to be an effective threshold for classifying at-risk plaques. This meta-analysis provides a more precise odds ratio with a narrow standard deviation that can be used to guide future studies.

Keywords: ACS; LRP; NIRS; Vulnerable plaque.

Publication types

Meta-Analysis
Systematic Review
Review

MeSH terms

Coronary Artery Disease*
Humans
Plaque, Atherosclerotic* / diagnostic imaging
Spectroscopy, Near-Infrared / methods