CCK-related peptides stimulation of the Na+/H+ antiport in pancreatic acinar cells leads to cytoplasmic alkalinisation

M J Bastie; M Dufresne; M Delvaux; N Vaysse; A Ribet

doi:10.1136/gut.28.suppl.85

CCK-related peptides stimulation of the Na+/H+ antiport in pancreatic acinar cells leads to cytoplasmic alkalinisation

Gut. 1987;28 Suppl(Suppl):85-8. doi: 10.1136/gut.28.suppl.85.

Authors

M J Bastie¹, M Dufresne, M Delvaux, N Vaysse, A Ribet

Affiliation

¹ U151 INSERM, CHU Rangueil, Toulouse, France.

Abstract

Caerulein, gastrin and pentagastrin stimulation of the Na+/H+ exchange leads to intracellular alkalinisation in pancreatic acinar cells. Activation of protein kinase-C is the more probable mechanism involved in the effect of caerulein.

MeSH terms

Animals
Biological Transport / drug effects
Ceruletide / pharmacology*
Cytoplasm / metabolism*
Gastrins / pharmacology*
Guinea Pigs
Hydrogen-Ion Concentration
Pancreas / drug effects*
Pancreas / metabolism
Pentagastrin / pharmacology*
Sodium / metabolism

Substances

Gastrins
Ceruletide
Sodium
Pentagastrin