A study has been made on the appearances in normal human sural nerve using freeze-fracture replication techniques. These have included qualitative observations on the major membrane systems and quantitative assessments of the density of intramembranous particles in the perineurial cell membranes, myelin, the nodal and internodal axolemma of myelinated nerve fibres and the axolemma of unmyelinated axons. The results have been compared with those obtained in other species.