p53 regulates the mitochondrial immune checkpoint

Claire Vanpouille-Box; Lorenzo Galluzzi

doi:10.1016/j.it.2023.03.001

p53 regulates the mitochondrial immune checkpoint

Trends Immunol. 2023 Apr;44(4):245-247. doi: 10.1016/j.it.2023.03.001. Epub 2023 Mar 16.

Authors

Claire Vanpouille-Box¹, Lorenzo Galluzzi²

Affiliations

¹ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA. Electronic address: [email protected].
² Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA. Electronic address: [email protected].

PMID: 36933950
DOI: 10.1016/j.it.2023.03.001

Abstract

Mitochondrial outer membrane permeabilization (MOMP) is crucial for the cytosolic accumulation of mitochondrial DNA (mtDNA) species that are required to jumpstart innate and adaptive immunity. Recent data reported by Ghosh et al. suggest that tumor protein p53 regulates MOMP-dependent type I interferon (IFN) production, not only via MOMP-promoting effects, but also by directing mtDNA-degrading exonucleases to proteasomal processing.

Keywords: BAX; BCL2; DNA-damage response; TRIM24; apoptosis.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
DNA, Mitochondrial / genetics
Humans
Mitochondria* / metabolism
Tumor Suppressor Protein p53* / genetics
Tumor Suppressor Protein p53* / metabolism

Substances

Tumor Suppressor Protein p53
DNA, Mitochondrial

Grants and funding

U54 CA274291/CA/NCI NIH HHS/United States