Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking

Leukemia. 2023 May;37(5):1147-1150. doi: 10.1038/s41375-023-01865-5. Epub 2023 Mar 22.

Dieter Weichenhan¹, Anna Riedel^{1

2}, Charlotte Meinen¹, Alisa Basic¹, Reka Toth^{1

3}, Marion Bähr¹, Pavlo Lutsik^{1

4}, Joschka Hey^{1

2}, Etienne Sollier^{1

2}, Umut H Toprak^{2

5}, Simge Kelekçi^{1

2}, Yu-Yu Lin¹, Mariam Hakobyan^{2

6}, Aurore Touzart^{1

7}, Ashish Goyal¹, Justyna A Wierzbinska^{1

2}, Matthias Schlesner⁸, Frank Westermann^{5

9}, Daniel B Lipka^#^{6

10}, Christoph Plass^#^{11

12}

¹ Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
² Faculty of Biosciences, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.
³ Luxembourg Institute of Health, Luxembourg, Luxembourg.
⁴ Department of Oncology KU Leuven, Leuven, Belgium.
⁵ Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁶ Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.
⁷ Université de Paris Cité, Institut Necker Enfants-Malades (INEM), Institut National de la Santé et de la Recherche Médicale (Inserm) U1151, and Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants-Malades, Paris, France.
⁸ Faculty of Applied Informatics, University of Augsburg, Augsburg, Germany.
⁹ Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
¹⁰ German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
¹¹ Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany. [email protected].
¹² German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany. [email protected].

^# Contributed equally.

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