Successful Treatment of Rare Pulmonary Coprinopsis cinerea Infection in a 17-Year-Old Female After Hematopoietic Stem Cell Transplantation: A Case Report

Infect Drug Resist. 2023 Mar 18:16:1567-1572. doi: 10.2147/IDR.S397233. eCollection 2023.

Abstract

Invasive fungal infections (IFIs) are among the most severe complications in recipients of hematopoietic stem cell transplantation (HSCT) recipients and in patients with hematological malignancies. An increasing number of uncommon fungal infections have been reported in this era of antifungal prophylaxis. Coprinopsis cinerea is a rare pathogen that causes opportunistic infections in the immunocompromised patients, including HSCT recipients and is associated with very high mortality rates. Herein, we present a successfully treated pediatric HSCT patient with breakthrough pulmonary IFI caused by Coprinopsis cinerea despite posaconazole, prophylaxis using multidisciplinary approaches.

Keywords: Coprinopsis cinerea; Hormographiella aspergillata; case report; hematopoietic stem cell transplantation; invasive fungal infection; leukemia.

Publication types

  • Case Reports

Grants and funding

This publication fee of this paper is funded by Shenzhen Science and Technology Innovation Commission (RCBS20200714114858018), Shenzhen Key Medical Discipline Construction Fund (SZXK034), Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties (SZGSP012), Shenzhen High-level Hospital Construction Fund, Shenzhen Children’s Hospital Research fund (ynkt2021-zz26, ynkt2020-zz01).