Molecularly imprinted electrochemical sensor based on synergistic interaction of honeycomb-like Ni-MOF decorated with AgNPs and N-GQDs for ultra-sensitive detection of olaquindox in animal-origin food

Food Chem. 2023 Aug 30:418:136001. doi: 10.1016/j.foodchem.2023.136001. Epub 2023 Mar 22.

Abstract

Olaquindox (OLA) in food from its illegal use possesses great harmful effects on humans, making it important to develop sensitive, inexpensive, and convenient methods for OLA detection. This study innovatively presented a molecularly imprinted electrochemical sensor based on the synergistic effects of nitrogen-doped graphene quantum dots (N-GQDs) and a nickel-based metal-organic framework functionalized with silver nanoparticles (Ag/Ni-MOF) for OLA detection. N-GQDs and Ag/Ni-MOF with unique honeycomb structures were sequentially modified on the glassy carbon electrode (GCE) surface to accelerate the electron transfer rate and increase the available region of the electrode. Molecularly imprinted polymers were further grown on the Ag/Ni-MOF/N-GQDs/GCE by electropolymerization to significantly enhance the selective recognition of OLA. The constructed sensor showed excellent performance for selective OLA determination, with a wide linear range (5-600 nmol·L-1) and exceedingly low detection limit (2.2 nmol·L-1). The sensor was successfully applied to detect OLA in animal-origin food with satisfactory recoveries (96.22-101.02%).

Keywords: Animal-origin food; Electrochemical sensor; MOF; Molecular imprinting; N-GQDs; Olaquindox.

MeSH terms

  • Animals
  • Carbon / chemistry
  • Electrochemical Techniques / methods
  • Electrodes
  • Food
  • Food Analysis
  • Graphite* / chemistry
  • Humans
  • Limit of Detection
  • Metal Nanoparticles* / chemistry
  • Molecular Imprinting* / methods
  • Nickel / chemistry
  • Nitrogen
  • Polymers / chemistry
  • Quantum Dots* / chemistry
  • Silver / chemistry

Substances

  • Carbon
  • Graphite
  • Nitrogen
  • olaquindox
  • Polymers
  • Silver
  • Nickel