Abstract
Three cases of allergic granulomatosis (Churg-Strauss syndrome) are reported. The patients all presented 2-10 years after the onset of pulmonary symptoms with a mononeuritis multiplex, accompanied by sharp pain in the extremities involved. In one patient, the neurological findings improved under treatment with corticoids and cyclophosphamide; the other two patients responded to treatment with thioguanine and cytarabine. In the first patient, the diagnosis was confirmed by a biopsy specimen of the sural nerve.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adrenal Cortex Hormones / therapeutic use
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Adult
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Antigen-Antibody Complex / analysis
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Axons / ultrastructure
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Cyclophosphamide / therapeutic use
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Cytarabine / therapeutic use
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Demyelinating Diseases / pathology
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Female
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Granuloma / drug therapy
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Granuloma / pathology*
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Humans
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Hypersensitivity / drug therapy
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Hypersensitivity / pathology*
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Middle Aged
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Muscles / pathology
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Neuromuscular Diseases / drug therapy
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Neuromuscular Diseases / pathology*
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Sural Nerve / pathology
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Syndrome
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Thioguanine / therapeutic use
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Vasculitis / pathology
Substances
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Adrenal Cortex Hormones
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Antigen-Antibody Complex
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Cytarabine
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Cyclophosphamide
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Thioguanine