A necrotic primary central nervous system lymphoma in immunocompetent patient with MYC and BCL6 rearrangements (double-hit lymphoma): a case report

Nabil C N Khalil; Bashaer Imad Iwaiwi; Shurooq Hammad; Afnan W M Jobran; Saeed Itkaidek; Elias Edward Lahham

doi:10.1093/omcr/omad026

A necrotic primary central nervous system lymphoma in immunocompetent patient with MYC and BCL6 rearrangements (double-hit lymphoma): a case report

Oxf Med Case Reports. 2023 Mar 25;2023(3):omad026. doi: 10.1093/omcr/omad026. eCollection 2023 Mar.

Authors

Nabil C N Khalil¹, Bashaer Imad Iwaiwi¹, Shurooq Hammad¹, Afnan W M Jobran¹, Saeed Itkaidek², Elias Edward Lahham¹

Affiliations

¹ Research Department, Faculty of Medicine, Al-Quds University, Jerusalem, Palestine.
² Department of Neurosurgery, Al-Ahli Hospital, Hebron, Palestine.

Abstract

Primary Central Nervous System Lymphoma (PCNSL) is a rare, aggressive extranodal non-Hodgkin lymphoma. It is critical to get a diagnosis and start therapy as soon as possible to improve clinical results. Despite a new medicinal strategy that has increased survivability, the survival rate is still quite low. This report presents a new case of PCNSL that appears in an immunocompetent patient with two different rare genetic rearrangements and a necrotic histological appearance.

Publication types

Case Reports