Etiology of Severe Acute Hepatitis in a Pediatric Transplant Center in Japan

Takanori Funaki; Masaki Yamada; Kentaro Ide; Reiko Ito; Kensuke Shoji; Chikara Ogimi; Ken-Ichi Imadome; Mureo Kasahara

doi:10.1093/jpids/piad021

Etiology of Severe Acute Hepatitis in a Pediatric Transplant Center in Japan

J Pediatric Infect Dis Soc. 2023 Apr 28;12(4):248-251. doi: 10.1093/jpids/piad021.

Authors

Takanori Funaki¹, Masaki Yamada^{1

2}, Kentaro Ide³, Reiko Ito⁴, Kensuke Shoji¹, Chikara Ogimi¹, Ken-Ichi Imadome², Mureo Kasahara⁵

Affiliations

¹ Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan.
² Department of Advanced Medicine for Viral Infections, National Center for Child Health and Development, Tokyo, Japan.
³ Department of Critical Care and Anesthesia, Critical Care Medicine, DepartnmNational Center for Child Health and Development, Tokyo, Japan.
⁴ Department of General Pediatrics and Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan.
⁵ Center for Organ Transplantation, National Center for Child Health and Development, Tokyo, Japan.

PMID: 36999626
DOI: 10.1093/jpids/piad021

Abstract

The proportion of pediatric cases with severe acute hepatitis of unknown etiology in the coronavirus disease 2019 era was higher than that in the pre-coronavirus disease 2019 era in Japan's largest pediatric transplant center. Further research and monitoring are essential.

Keywords: children; etiology; liver failure; liver transplantation; severe acute hepatitis.

© The Author(s) 2023. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: [email protected].

MeSH terms

COVID-19*
Child
Hepatitis* / etiology
Humans
Japan
Liver Transplantation* / adverse effects

Grants and funding

2022B-15 to TF/National Center for Child Health and Development