The Past, Present, and Future of Noninvasive Test in Chronic Liver Diseases

Med Clin North Am. 2023 May;107(3):397-421. doi: 10.1016/j.mcna.2022.12.001. Epub 2023 Feb 20.

Abstract

Chronic liver disease is a major global health threat and is the 11th leading cause of death globally. A liver biopsy is frequently required in assessing the degree of steatosis and fibrosis, information that is important in diagnosis, management, and prognostication. However, liver biopsies have limitations and carry a considerable risk, leading to the development of various modalities of noninvasive testing tools. These tools have been developed in recent years and have improved markedly in diagnostic accuracy. Moving forward, they may change the practice of hepatology.

Keywords: Chronic liver disease; Fibrosis; Noninvasive test; Steatosis.

Publication types

  • Review

MeSH terms

  • Biomarkers
  • Biopsy / adverse effects
  • Elasticity Imaging Techniques* / adverse effects
  • Humans
  • Liver / pathology
  • Liver Cirrhosis / diagnosis
  • Non-alcoholic Fatty Liver Disease* / complications
  • Non-alcoholic Fatty Liver Disease* / diagnosis

Substances

  • Biomarkers