Cytomegalovirus Uveitis: Taiwan expert consensus

Wei-Yu Chiang; Chang-Ping Lin; Wan-Hua Cho; Chang-Hao Yang; San-Ni Chen; Yih-Shiou Hwang; Sheng-Min Hsu; De-Kuang Hwang; Shih-Chou Chen; Hsi-Kung Kuo; Shwu-Jiuan Sheu

doi:10.1016/j.jfma.2023.03.014

Cytomegalovirus Uveitis: Taiwan expert consensus

J Formos Med Assoc. 2023 Aug;122(8):668-674. doi: 10.1016/j.jfma.2023.03.014. Epub 2023 Mar 30.

Authors

Wei-Yu Chiang¹, Chang-Ping Lin², Wan-Hua Cho³, Chang-Hao Yang⁴, San-Ni Chen⁵, Yih-Shiou Hwang⁶, Sheng-Min Hsu⁷, De-Kuang Hwang⁸, Shih-Chou Chen⁹, Hsi-Kung Kuo¹⁰, Shwu-Jiuan Sheu¹¹

Affiliations

¹ Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan; School of Medicine, Chang Gung University, Taoyuan City, Taiwan.
² Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
³ Department of Ophthalmology, Chi Mei Medical Center, Tainan, Taiwan.
⁴ Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan; Department of Ophthalmology, College of Medicine, National Taiwan University, Taipei, Taiwan.
⁵ Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan.
⁶ School of Medicine, Chang Gung University, Taoyuan City, Taiwan; Department of Ophthalmology, Chang Gung Memorial Hospital, Guishan District, Taoyuan City, Taiwan.
⁷ Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁸ Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
⁹ Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
¹⁰ Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan; School of Medicine, Chang Gung University, Taoyuan City, Taiwan. Electronic address: [email protected].
¹¹ Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: [email protected].

PMID: 37003913
DOI: 10.1016/j.jfma.2023.03.014

Abstract

Cytomegalovirus (CMV) uveitis, a type of herpetic uveitis, is a major cause of infectious uveitis. Anterior and posterior CMV uveitis have diverse clinical presentations and treatment modalities. Based on expert consensus in Taiwan, this article provides suggestions regarding clinical manifestations, diagnosis, and treatment strategies for CMV uveitis based on clinical practice experience in Taiwan. CMV uveitis may have a distinct clinical presentation. Polymerase chain reaction (PCR) is an essential diagnostic tool to confirm a diagnosis. Antiviral therapy is the mainstay of treatment. Different agents, routes, and other supplemental treatments have been summarized and discussed in this article. Early diagnosis and appropriate treatment of CMV uveitis are crucial to avoid irreversible complications and vision loss. This consensus provides practical guidelines for ophthalmologists in Taiwan.

Keywords: CMV; Consensus; Herpetic virus; Taiwan; Uveitis.

Publication types

Practice Guideline

MeSH terms

Consensus
Cytomegalovirus / genetics
Cytomegalovirus Infections* / diagnosis
Cytomegalovirus Infections* / drug therapy
DNA, Viral
Eye Infections, Viral* / diagnosis
Eye Infections, Viral* / drug therapy
Humans
Taiwan
Uveitis* / diagnosis
Uveitis* / drug therapy
Uveitis* / etiology
Uveitis, Anterior* / diagnosis
Uveitis, Anterior* / drug therapy

Substances

DNA, Viral