It takes two to untangle: Combined stimulation of adult neurogenesis reverts AD symptoms

Rut Gabarró-Solanas; Noelia Urbán

doi:10.1016/j.stem.2023.03.012

It takes two to untangle: Combined stimulation of adult neurogenesis reverts AD symptoms

Cell Stem Cell. 2023 Apr 6;30(4):333-334. doi: 10.1016/j.stem.2023.03.012.

Authors

Rut Gabarró-Solanas¹, Noelia Urbán²

Affiliations

¹ Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria; Vienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna, 1030, Vienna, Austria. Electronic address: [email protected].
² Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria. Electronic address: [email protected].

PMID: 37028395
DOI: 10.1016/j.stem.2023.03.012

Abstract

Alzheimer's disease (AD) is associated with reduced adult hippocampal neurogenesis and impaired hippocampal-dependent behaviors. Li et al.¹ report that stimulating adult neurogenesis combined with new-born neuron activation ameliorates behavioral symptoms and plaque deposition in AD mouse models. This supports boosting adult neurogenesis as a potential therapeutic approach for AD-related cognitive decline.

Publication types

Comment

MeSH terms

Alzheimer Disease* / therapy
Animals
Disease Models, Animal
Hippocampus
Mice
Mice, Transgenic
Neurogenesis / physiology
Neurons

Grants and funding

DOC 72/FWF_/Austrian Science Fund FWF/Austria