Preventative Care in Scleroderma: What Is the Best Approach to Bone Health and Cancer Screening?

Rheum Dis Clin North Am. 2023 May;49(2):411-423. doi: 10.1016/j.rdc.2023.01.011.

Abstract

Systemic sclerosis (SSc) is a rare multisystem autoimmune disease characterized by fibrosis, vasculopathy, and autoimmunity. Lesser known complications inherent to SSc, such as malignancies and osteoporosis, can lead to decreased quality of life and increased morbidity and mortality. Patients with SSc have a greater risk of developing malignancies than the general population. In addition, they are more likely to be vitamin D deficient and are at great risk of osteoporosis-related fractures. However, these complications can be addressed through preventative measures. The purpose of this review is to provide clinicians with an approach to bone health and cancer screening in SSc.

Keywords: Avascular necrosis; Cancer screening; Fracture; Osteoporosis; Prevention; Scleroderma; Systemic sclerosis.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Bone Density
  • Early Detection of Cancer
  • Humans
  • Neoplasms* / diagnosis
  • Neoplasms* / epidemiology
  • Neoplasms* / prevention & control
  • Osteoporosis* / diagnosis
  • Osteoporosis* / etiology
  • Osteoporosis* / prevention & control
  • Osteoporotic Fractures*
  • Quality of Life
  • Scleroderma, Systemic* / complications
  • Scleroderma, Systemic* / diagnosis