Trichophyton indotineae, from epidemiology to therapeutic

Arnaud Jabet; Anne-Cécile Normand; Sophie Brun; Eric Dannaoui; Claude Bachmeyer; Renaud Piarroux; Christophe Hennequin; Alicia Moreno-Sabater

doi:10.1016/j.mycmed.2023.101383

Trichophyton indotineae, from epidemiology to therapeutic

J Mycol Med. 2023 Aug;33(3):101383. doi: 10.1016/j.mycmed.2023.101383. Epub 2023 Mar 29.

Authors

Arnaud Jabet¹, Anne-Cécile Normand², Sophie Brun³, Eric Dannaoui⁴, Claude Bachmeyer⁵, Renaud Piarroux⁶, Christophe Hennequin⁷, Alicia Moreno-Sabater⁸

Affiliations

¹ Service de Parasitologie-Mycologie, Hôpital Saint-Antoine, AP-HP, 75012 Paris, France; Service de Parasitologie-Mycologie, Hôpital La Pitié-Salpêtrière, AP-HP, 75013 Paris, France. Electronic address: [email protected].
² Service de Parasitologie-Mycologie, Hôpital La Pitié-Salpêtrière, AP-HP, 75013 Paris, France.
³ Service de Parasitologie-Mycologie, Hôpital Avicenne, AP-HP, 93009 Bobigny, France.
⁴ Unité de Parasitologie-Mycologie, Service de Microbiologie, Hôpital Necker, AP-HP, 75015 Paris, France; UR Dynamic 7380, UPEC, EnvA, USC ANSES, Faculté de Santé, 94000 Créteil, France; Faculté de Médecine, Université Paris Cité, 75006 Paris, France.
⁵ Service de Médecine interne, Hôpital Tenon, AP-HP, 75020 Paris, France.
⁶ Service de Parasitologie-Mycologie, Hôpital La Pitié-Salpêtrière, AP-HP, 75013 Paris, France; Institut Pierre Louis d'Épidémiologie et de Santé Publique, Inserm, Sorbonne Université, 75013 Paris, France.
⁷ Service de Parasitologie-Mycologie, Hôpital Saint-Antoine, AP-HP, 75012 Paris, France; Centre de Recherche Saint-Antoine, CRSA, Inserm, Sorbonne Université, 75012 Paris, France.
⁸ Service de Parasitologie-Mycologie, Hôpital Saint-Antoine, AP-HP, 75012 Paris, France; Centre d'Immunologie et des Maladies Infectieuses, (CIMI-PARIS), Inserm U1135, Sorbonne, 75013 Paris, France.

PMID: 37031652
DOI: 10.1016/j.mycmed.2023.101383

Abstract

Trichophyton indotineae is a newly described dermatophyte species. This fungal pathogen has recently emerged in India and is responsible for chronic or recurrent widespread superficial infections. Resistance to terbinafine is frequently associated to this pathogen and is related to point mutations in the gene encoding the squalene epoxidase. T. indotineae infections have been reported outside India, highlighting the risk of worldwide diffusion of this microorganism. Species identification and antifungal susceptibility determination are key points for infection control but still remain challenging. Systemic treatment is usually required and itraconazole is frequently prescribed in case of terbinafine resistance. This review summarizes main features of T. indotineae taxonomy, epidemiology, clinical manifestations, identification, antifungal profile, treatment and prevention.

Keywords: Antifungal resistance; Dermatophytes; Itraconazole; Terbinafine; Trichophyton indotineae; Trichophyton mentagrophytes.

Publication types

Review

MeSH terms

Antifungal Agents* / pharmacology
Antifungal Agents* / therapeutic use
Arthrodermataceae*
Drug Resistance, Fungal
Microbial Sensitivity Tests
Terbinafine / therapeutic use
Trichophyton

Substances

Antifungal Agents
Terbinafine