Mesotherapy-Induced Cutaneous Foreign Body-Type Granulomatous Reaction in the Face Treated with Minocycline: Case Report and Literature Review

Qian Zhang; Lihua Yang; Fengjuan Yang; Lian Liu; Xian Jiang

doi:10.2147/CCID.S403601

Mesotherapy-Induced Cutaneous Foreign Body-Type Granulomatous Reaction in the Face Treated with Minocycline: Case Report and Literature Review

Clin Cosmet Investig Dermatol. 2023 Apr 3:16:861-867. doi: 10.2147/CCID.S403601. eCollection 2023.

Authors

Qian Zhang^#¹, Lihua Yang^#¹, Fengjuan Yang¹, Lian Liu¹, Xian Jiang^{1

2}

Affiliations

¹ Department of Dermatology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
² Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

^# Contributed equally.

Abstract

Mesotherapy is a popular treatment that delivers substances deep into the skin but induces foreign body-type granulomatous reactions. However, such reactions caused by unauthorized use of topical tranexamic acid products in mesotherapy have never been reported before. We herein demonstrated a case of a 33-year-old woman with multiple mesotherapy-induced foreign body-type granulomas disseminated across her face. The patient was diagnosed with echo-color Doppler (ECD) and successfully treated with medications including minocycline hydrochloride. Then, we reviewed the differential diagnosis and current treatment for foreign body-type granulomatous reaction.

Keywords: face; foreign body-type granulomatous reaction; mesotherapy; minocycline; tranexamic acid.

Publication types

Case Reports

Grants and funding

This study was supported by Clinical Research Innovation Project, West China Hospital, Sichuan University (grant no. 19HXCX010) and the National Natural Science Foundation of China (grant no. 82273559).