Asthma is one of the most common chronic diseases affecting the pediatric population. The diagnosis and management of asthma is constantly evolving, and recently the National Heart, Lung, and Blood Institute published an updated guideline regarding various aspects of pediatric asthma. In this report, we review and summarize these guidelines and compare them with the Global Initiative for Asthma guidelines. [Pediatr Ann. 2023;52(4):e153-e158.].